3032487-31-0
3032487-31-0
Chemical Structure
BAY-9835
- CAS No.: 3032487-31-0
- Formula:C22H16F5N5O3
- Molecular Weight:493.39
InChIKey: LPQXZOJIUVOCAL-NRFANRHFSA-N
SMILES: O=C(C1=CC=C(F)C(F)=C1C2=CC=C(C(F)(F)F)C=C2)NC[C@@](C(N3)=O)(C4=CC=NN4C)NC3=O
Biological Activity: BAY-9835, a chemical probe, is an orally active ADAMTS7 and ADAMTS12 antagonist with IC50s of 6 nM and 30 nM, respectively. BAY-9835 exhibits inhibitory potencies vs mouse (mIC50 = 8 nM) and rat (rIC50 = 27 nM) ADAMTS7 enzymes. BAY-9835 is very selective against a range of off-targets and metalloproteases. BAY-9835 can be used for the study of atherogenesis[1].
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BAY-9835 | 99.46% | BAY-9835, a chemical probe, is an orally active ADAMTS7 and ADAMTS12 antagonist with IC50s of 6 nM and 30 nM, respectively. BAY-9835 exhibits inhibitory potencies vs mouse (mIC50 = 8 nM) and rat (rIC50 = 27 nM) ADAMTS7 enzymes. BAY-9835 is very selective against a range of off-targets and metalloproteases. BAY-9835 can be used for the study of atherogenesis. | ||||||||||||||||||||
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References
Keywords
