3032646-96-8
Chemical Structure
QC-182
- CAS No.: 3032646-96-8
- Formula:C44H42F2N8O6
- Molecular Weight:816.85
InChIKey: OCWNROZULZWRQM-NWDJCJOJSA-N
SMILES: O=C1N(C2C(NC(CC2)=O)=O)C(C(C1=C3)=CC=C3N(C4)CC4N5CCC(N6C7=CC=C(C8=C(C)ON=C8C)C=C7N=C6[C@H]9N(C%10=CC(F)=C(F)C=C%10)C(CCC9)=O)CC5)=O
Biological Activity: QC-182 is a p300/CBP PROTAC degrader with a DC50 of 93 nM against p300. QC-182 induces ubiquitination and proteasomal degradation of p300 and CBP in a CRBN-dependent manner. QC-182 induces Apoptosis. QC-182 exhibits anticancer activity against liver cancer cells. QC-182 can be used for the research of hepatocellular carcinoma[1].
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QC-182 | 98.94% | QC-182 is a p300/CBP PROTAC degrader with a DC50 of 93 nM against p300. QC-182 induces ubiquitination and proteasomal degradation of p300 and CBP in a CRBN-dependent manner. QC-182 induces Apoptosis. QC-182 exhibits anticancer activity against liver cancer cells. QC-182 can be used for the research of hepatocellular carcinoma. | ||||||||||||||||||||
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Keywords
