3032785-06-8
Chemical Structure
PROTAC CARM1 degrader-2
- CAS No.: 3032785-06-8
- Formula:C72H100N12O7S
- Molecular Weight:1277.71
InChIKey: WRQKOZXHYYEKER-KLLGSTGQSA-N
SMILES: O=C([C@H]1N(C([C@@H](NC(CN2CCN(CC3CCN(CC4CCN(C(CCC5=CC=C(OC6=CC=CC(C(N(C)CC7=CC(C8CCN(CCNC)CC8)=NC=C7)=O)=C6)C=C5)=O)CC4)CC3)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C9=CC=C(C%10=C(C)N=CS%10)C=C9)C
Biological Activity: PROTAC CARM1 degrader-2 is a selective PROTAC-based CARM1 degrader with a DC50 of 8.8 nM in breast cancer cells. PROTAC CARM1 degrader-2 mediates CARM1 protein degradation in a ubiquitin ligase- and proteasome-dependent manner, and reduces the methylation level of downstream substrates of CARM1. PROTAC CARM1 degrader-2 can be used in breast cancer-related research[1].
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PROTAC CARM1 degrader-2 | PROTAC CARM1 degrader-2 is a selective PROTAC-based CARM1 degrader with a DC50 of 8.8 nM in breast cancer cells. PROTAC CARM1 degrader-2 mediates CARM1 protein degradation in a ubiquitin ligase- and proteasome-dependent manner, and reduces the methylation level of downstream substrates of CARM1. PROTAC CARM1 degrader-2 can be used in breast cancer-related research. | |||||||||||||||||||||
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