3033645-28-9
Chemical Structure
Chitin synthase inhibitor 5
- CAS No.: 3033645-28-9
- Formula:C23H22BrN3O5
- Molecular Weight:500.34
IUPAC Name: (E)-N-(4-bromophenyl)-4-(6-methoxy-2-oxo-1,2-dihydrospiro[benzo[d][1,3]oxazine-4,4'-piperidin]-1'-yl)-4-oxobut-2-enamide
InChIKey: OGFJSCZAUVWZAU-CMDGGOBGSA-N
SMILES: COC1=CC2=C(NC(OC23CCN(CC3)C(/C=C/C(NC4=CC=C(C=C4)Br)=O)=O)=O)C=C1
Biological Activity: Chitin synthase inhibitor 5 (compound 9a) is an inhibitor of chitin synthase with an IC50 value of 0.14 mM. Chitin synthase inhibitor 5 shows broad-spectrum antifungal activity in vitro and shows good inhibition to C. albicans, A. flavus, A. fumigatus and C. neoformans. Chitin synthase inhibitor 5 can be used for the research of fungal[1].
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Chitin synthase inhibitor 5 | Chitin synthase inhibitor 5 (compound 9a) is an inhibitor of chitin synthase with an IC50 value of 0.14 mM. Chitin synthase inhibitor 5 shows broad-spectrum antifungal activity in vitro and shows good inhibition to C. albicans, A. flavus, A. fumigatus and C. neoformans. Chitin synthase inhibitor 5 can be used for the research of fungal. | |||||||||||||||||||||
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Keywords
