3036387-75-1
Chemical Structure
HEP-50768
- CAS No.: 3036387-75-1
- Formula:C16H10F4N4O
- Molecular Weight:350.27
InChIKey: DNYWMBQGFDLRHS-ZDUSSCGKSA-N
SMILES: FC1=C(C2=NN=NN2)C=CC=C1[C@@H]3CC4=CC(C(F)(F)F)=CC=C4O3
Biological Activity: HEP-50768 is an orally active and selective MRGPRX4 (hX4) antagonist. HEP-50768 suppresses basal and bile-acid-stimulated hX4 activity. HEP-50768 binds the receptor’s transmembrane pocket and induces extracellular loop rearrangements. HEP-50768 modulates GPCR microswitch motifs and reduces bile-acid-induced pruritic scratching behaviors. HEP-50768 can be used for the research of cholestatic pruritus[1].
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HEP-50768 | 99.17% | HEP-50768 is an orally active and selective MRGPRX4 (hX4) antagonist. HEP-50768 suppresses basal and bile-acid-stimulated hX4 activity. HEP-50768 binds the receptor’s transmembrane pocket and induces extracellular loop rearrangements. HEP-50768 modulates GPCR microswitch motifs and reduces bile-acid-induced pruritic scratching behaviors. HEP-50768 can be used for the research of cholestatic pruritus. | ||||||||||||||||||||
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Keywords
