3038691-79-8
3038691-79-8
Chemical Structure
HR488B
- CAS No.: 3038691-79-8
- Formula:C24H26ClN3O4S
- Molecular Weight:488.00
InChIKey: XAOFTTATCDLUAN-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)N(C(CCCCCC(NO)=O)=O)CC2=NC(C3=CC=CC=C3Cl)=CS2
Biological Activity: HR488B is an efficient HDAC1 inhibitor. HR488B specifically suppressed the growth of CRC cells by inducing cell cycle G0/G1 arrest and apoptosis. HR488B causes mitochondrial dysfunction, reactive oxygen species (ROS) generation, and DNA damage accumulation[1].
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HR488B | HR488B is an efficient HDAC1 inhibitor. HR488B specifically suppressed the growth of CRC cells by inducing cell cycle G0/G1 arrest and apoptosis. HR488B causes mitochondrial dysfunction, reactive oxygen species (ROS) generation, and DNA damage accumulation. | |||||||||||||||||||||
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References
Keywords
