3039488-61-1
3039488-61-1
Chemical Structure
DGKα&ζ-IN-2
- CAS No.: 3039488-61-1
- Formula:C35H34F4N6O2
- Molecular Weight:646.68
SMILES: F/C(C1=NC(C2=CC=NN=C2)=CN=C1)=C\C3=CC=C(C(C(F)(F)F)=C3N4CCOC5(C4)CCN(CC5)CC6CC6)OC7=CC=CC=C7
Biological Activity: DGKα/ζ-IN-2 is a potent, orally active and selective dual DGKα/ζ inhibitor with IC50 values of 23 nM (DGKα) and 1.2 nM (DGKζ). DGKα/ζ-IN-2 exhibits selectivity over other DGK isoforms, such as DGKβ and DGKγ. DGKα/ζ-IN-2 shows robust and dose-dependent immune activation in the presence of antigen presentation in an OT-1 murine model. DGKα/ζ-IN-2 can be used for antitumor immunity[1].
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DGKα&ζ-IN-2 | DGKα/ζ-IN-2 is a potent, orally active and selective dual DGKα/ζ inhibitor with IC50 values of 23 nM (DGKα) and 1.2 nM (DGKζ). DGKα/ζ-IN-2 exhibits selectivity over other DGK isoforms, such as DGKβ and DGKγ. DGKα/ζ-IN-2 shows robust and dose-dependent immune activation in the presence of antigen presentation in an OT-1 murine model. DGKα/ζ-IN-2 can be used for antitumor immunity. | |||||||||||||||||||||
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References
Keywords
