3063720-23-7

Proteasome-IN-6 Chemical Structure
3063720-23-7

Chemical Structure

Proteasome-IN-6

  • CAS No.: 3063720-23-7
  • Formula:C35H45F3N4O6
  • Molecular Weight:674.75

InChIKey: HBWKWIZWKVVYJN-LYNDRFBJSA-N

SMILES: CCCCCC(N[C@H](CC(N(CC)CC)=O)C(N[C@@H](CC1=CC=C(F)C=C1)C(N[C@@H](CC2=CC=C(F)C=C2F)C([C@@]3(C)CO3)=O)=O)=O)=O

Biological Activity: Proteasome-IN-6 (Compound J-80) inhibits the β5 catalytic subunit of the Trypanosoma brucei 20S proteasome, inibits T. b. brucei, T. b. gambiense and T. b. rhodesiense with EC50s of 157 nM, 220 nM and 156 nM, respectively. Proteasome-IN-6 exhibits antitrypanosomal activity in mouse model[1].

Cat. No. Product Name Purity Description Pricing
HY-170363 		Proteasome-IN-6 Proteasome-IN-6 (Compound J-80) inhibits the β5 catalytic subunit of the Trypanosoma brucei 20S proteasome, inibits T. b. brucei, T. b. gambiense and T. b. rhodesiense with EC50s of 157 nM, 220 nM and 156 nM, respectively. Proteasome-IN-6 exhibits antitrypanosomal activity in mouse model.
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