3071873-52-1
3071873-52-1
Chemical Structure
PAD4-IN-5
- CAS No.: 3071873-52-1
- Formula:C34H41N7O3
- Molecular Weight:595.73
InChIKey: QOJRPKKJRLQHIW-KZKYLIHBSA-N
SMILES: O=C1C2=C(C=C(N(C)C(C3=CC4=C(N=C([C@H](N5)C)C=C4)N3CCCCC[C@@H]6C[C@H]6C5=O)=N7)C7=C2)CCN1C[C@H]8COCCN8
Biological Activity: PAD4-IN-5 (Example 18) is a PAD4 inhibitor with IC50s of ≤10 nM and 101-500 nM for human PAD4 (hPAD4) under 50 µM Ca2+ and 1 mM Ca2+ conditions, respectively. PAD4-IN-5 can be used for the study of autoimmune disease, such as rheumatoid arthritis (RA)[1].
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PAD4-IN-5 | PAD4-IN-5 (Example 18) is a PAD4 inhibitor with IC50s of ≤10 nM and 101-500 nM for human PAD4 (hPAD4) under 50 µM Ca2+ and 1 mM Ca2+ conditions, respectively. PAD4-IN-5 can be used for the study of autoimmune disease, such as rheumatoid arthritis (RA). | |||||||||||||||||||||
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References
Keywords
