3076612-97-7
Chemical Structure
TKP-5
- CAS No.: 3076612-97-7
- Formula:C44H47N7O10
- Molecular Weight:833.88
InChIKey: LVWNPZYAXUTHIA-NBVRZTHBSA-N
SMILES: O=C(C)NCCC1=C(C(/C=C/C2=CC=C(OCC3=CN(CCCCCC(NC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)=O)N=N3)C=C2)=O)C=C(OCC)C(OC)=C1
Biological Activity: TKP-5 is a PROTAC protein degrader targeting BRD4. TKP-5 can binds to BRD2, BRD3, BRD4 and BRDT, with Kd values of 150 nM, 100 nM and 150 nM for the first three proteins respectively. TKP-5 inhibits the production of thymic stromal lymphopoietin and suppresses the expression of IL-33 mRNA. TKP-5 is applicable to studies related to tape-stripping induced skin injury[1].
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TKP-5 | TKP-5 is a PROTAC protein degrader targeting BRD4. TKP-5 can binds to BRD2, BRD3, BRD4 and BRDT, with Kd values of 150 nM, 100 nM and 150 nM for the first three proteins respectively. TKP-5 inhibits the production of thymic stromal lymphopoietin and suppresses the expression of IL-33 mRNA. TKP-5 is applicable to studies related to tape-stripping induced skin injury. | |||||||||||||||||||||
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Keywords
