3106363-91-8
Chemical Structure
Bfl-1-IN-6
- CAS No.: 3106363-91-8
- Formula:C22H24ClFN2O2
- Molecular Weight:402.89
InChIKey: PDKKJSNSPGZTJL-POZUXBRTSA-N
SMILES: O=C(N([C@@H](C)C1=CC=C(Cl)C=C1)C2=CC(F)=C(O[C@@H]3CC[C@@H](N)C3)C=C2)C=C
Biological Activity: Bfl-1-IN-6 is an orally active BFL1 inhibitor with an IC50 of 19 nM. Bfl-1-IN-6 selectively binds covalently to BFL1, stabilizes the protein and displaces BIM from BFL1, thereby inducing apoptosis activity. Bfl-1-IN-6 stabilizes BFL1 protein, activates cleaved caspase 3, and exhibits antitumor activity in mouse models. Bfl-1-IN-6 can be used for the research of hematological malignancies[1].
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Bfl-1-IN-6 | Bfl-1-IN-6 is an orally active BFL1 inhibitor with an IC50 of 19 nM. Bfl-1-IN-6 selectively binds covalently to BFL1, stabilizes the protein and displaces BIM from BFL1, thereby inducing apoptosis activity. Bfl-1-IN-6 stabilizes BFL1 protein, activates cleaved caspase 3, and exhibits antitumor activity in mouse models. Bfl-1-IN-6 can be used for the research of hematological malignancies. | |||||||||||||||||||||
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Keywords
