31077-70-0
Chemical Structure
3''-Deamino-3''-hydroxykanamycin B
Synonym(s): NK-1012-1
- CAS No.: 31077-70-0
- Formula:C18H36N4O11
- Molecular Weight:484.50
IUPAC Name: (2S,3R,4S,5S,6R)-2-(((1S,2S,3R,4S,6R)-4,6-diamino-3-(((2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
InChIKey: MOWMHIINUAQFMU-DNBVWFFRSA-N
SMILES: O([C@H]1[C@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](N)C[C@@H]1N)[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N
Biological Activity: 3''-Deamino-3''-hydroxykanamycin B (NK-1012-1) is a kanamycin antibiotic. 3''-Deamino-3''-hydroxykanamycin B can be produced by S. tenebrarius. 3''-Deamino-3''-hydroxykanamycin B is effective against E. coli ATCC 25922 and E. coli CCARM 1A020, with MIC values of 128 μg/mL[1][2].
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3''-Deamino-3''-hydroxykanamycin B | 3''-Deamino-3''-hydroxykanamycin B (NK-1012-1) is a kanamycin antibiotic. 3''-Deamino-3''-hydroxykanamycin B can be produced by S. tenebrarius. 3''-Deamino-3''-hydroxykanamycin B is effective against E. coli ATCC 25922 and E. coli CCARM 1A020, with MIC values of 128 μg/mL. | |||||||||||||||||||||
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- [1]. Yeo Joon Yoon, et al. A new kanamycin compound, kanamycin-producing streptomyces species bacterium, and method of producing kanamycin. WO2011132830A1. WIPO (PCT). 2010-10-14.
- [2]. Park JW, et al. The nebramycin aminoglycoside profiles of Streptomyces tenebrarius and their characterization using an integrated liquid chromatography-electrospray ionization-tandem mass spectrometric analysis. Anal Chim Acta. 2010 Feb 19;661(1):76-84. [Content Brief]
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