3115269-32-1
3115269-32-1
Chemical Structure
DHC-156
- CAS No.: 3115269-32-1
- Formula:C24H24F4N4O3
- Molecular Weight:492.47
InChIKey: SBZOWNJIUPEINK-SNAWJCMRSA-N
SMILES: COC1=C(C=C2C(C=CN=C2NC3=CC(OCC(F)(F)F)=C(C=C3)F)=C1)NC(/C=C/CN(C)C)=O
Biological Activity: DHC-156 is a selective Brachyury downregulator. DHC-156 induces post-translational downregulation via covalent binding and exerts pre-translational inhibition through autoregulation, independent of proteasome- or lysosome-dependent degradation pathways. DHC-156 can be used in chordoma-related research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
DHC-156 | 99.54% | DHC-156 is a selective Brachyury downregulator. DHC-156 induces post-translational downregulation via covalent binding and exerts pre-translational inhibition through autoregulation, independent of proteasome- or lysosome-dependent degradation pathways. DHC-156 can be used in chordoma-related research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Chase DH, et al. Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury. Angewandte Chemie (International ed. in English). 2024 Apr 02;63(14):e202316496. [Content Brief]
- [2]. Caneve P, et al. Brachyury expression is highly specific for chordoma: A tissue microarray study involving 14,976 cancers from 135 different tumor types and subtypes. Annals of diagnostic pathology. 2025 Jun;76:152448.
Keywords
