3116073-35-6
3116073-35-6
Chemical Structure
CD28-IN-4
- CAS No.: 3116073-35-6
- Formula:C19H20ClN5O3
- Molecular Weight:401.85
InChIKey: FOPSPXWMDKKAHP-UHFFFAOYSA-N
SMILES: ClC1=CN2C(C=C1)=CC(C(N3CC(CN4C=C(CCC(O)=O)N=N4)CC3)=O)=C2
Biological Activity: CD28-IN-4 is a selective CD28 inhibitor with a human IC50 of 231 nM and a human Kd of 344 nM. CD28-IN-4 binds to CD28, disrupts its interaction with CD80, blocks CD28-mediated co-stimulatory signal transduction, and reduces cytokine secretion in a human primary tumor-PBMC and epithelial tissue co-culture model. CD28-IN-4 can be used for cancer-related research[1].
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CD28-IN-4 | CD28-IN-4 is a selective CD28 inhibitor with a human IC50 of 231 nM and a human Kd of 344 nM. CD28-IN-4 binds to CD28, disrupts its interaction with CD80, blocks CD28-mediated co-stimulatory signal transduction, and reduces cytokine secretion in a human primary tumor-PBMC and epithelial tissue co-culture model. CD28-IN-4 can be used for cancer-related research. | |||||||||||||||||||||
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References
Keywords
