3119834-80-6
Chemical Structure
Bcl-2-IN-26
- CAS No.: 3119834-80-6
- Formula:C20H16F2N2O4
- Molecular Weight:386.35
InChIKey: HFKPOJBYFBNGGU-LWHVZEOZSA-N
SMILES: FC1=CC(F)=CC(/C=C2NC(/C(NC\2=O)=C/C3=CC=C(COCC=C)O3)=O)=C1
Biological Activity: Bcl-2-IN-26 is an inhibitor targeting β-tubulin and BCL-2. Bcl-2-IN-26 disrupts the intracellular microtubule network and interferes with cell mitosis, inducing G2/M phase cell cycle arrest. Bcl-2-IN-26 suppresses antiapoptotic BCL-2 function via p53 upregulation, thereby triggering mitochondrial dysfunction, elevated ROS production and robust tumor cell apoptosis. Bcl-2-IN-26 can be used in lung cancer research[1].
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Bcl-2-IN-26 | Bcl-2-IN-26 is an inhibitor targeting β-tubulin and BCL-2. Bcl-2-IN-26 disrupts the intracellular microtubule network and interferes with cell mitosis, inducing G2/M phase cell cycle arrest. Bcl-2-IN-26 suppresses antiapoptotic BCL-2 function via p53 upregulation, thereby triggering mitochondrial dysfunction, elevated ROS production and robust tumor cell apoptosis. Bcl-2-IN-26 can be used in lung cancer research. | |||||||||||||||||||||
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Keywords
