3133169-21-5
3133169-21-5
Chemical Structure
CCNE1 degrader-2
- CAS No.: 3133169-21-5
- Formula:C30H27FN4O5
- Molecular Weight:542.56
InChIKey: AOINHIVVWZBXMH-MDYZWHIJSA-N
SMILES: O=C1N(C2C(NC(CC2)=O)=O)CC3=CC=C(N4[C@H](CN(C5=CC=C(C=C5)OC6=CC=C(C=C6)F)C(C4)=O)C)C=C31
Biological Activity: CCNE1 degrader-2 is an orally active CCNE1 degrader with a paDC50 of 7.7 nM. CCNE1 degrader-2 promotes the targeted degradation of Cyclin E1 protein. CCNE1 degrader-2 inhibits tumor cell proliferation and exerts antitumor activity in CDX in vivo models. CCNE1 degrader-2 is used in research on cancers such as ovarian cancer and breast cancer[1].
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CCNE1 degrader-2 | CCNE1 degrader-2 is an orally active CCNE1 degrader with a paDC50 of 7.7 nM. CCNE1 degrader-2 promotes the targeted degradation of Cyclin E1 protein. CCNE1 degrader-2 inhibits tumor cell proliferation and exerts antitumor activity in CDX in vivo models. CCNE1 degrader-2 is used in research on cancers such as ovarian cancer and breast cancer. | |||||||||||||||||||||
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