354759-10-7
354759-10-7
Chemical Structure
PBOX-15
- CAS No.: 354759-10-7
- Formula:C28H19NO3
- Molecular Weight:417.46
IUPAC Name: 5-(naphthalen-1-yl)naphtho[2,3-b]pyrrolo[1,2-d][1,4]oxazepin-4-yl acetate
InChIKey: STVDRIIZTGYIMM-UHFFFAOYSA-N
SMILES: O=C(C)OC1=C(C2=C3C=CC=CC3=CC=C2)OC4=CC5=C(C=C4N6C=CC=C16)C=CC=C5
Biological Activity: PBOX-15 is a microtubule targeting agent. PBOX-15 induces apoptosis by promoting tubulin depolymerization in tumor cells[1][2].
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PBOX-15 | PBOX-15 is a microtubule targeting agent. PBOX-15 induces apoptosis by promoting tubulin depolymerization in tumor cells. | |||||||||||||||||||||
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References
- [1]. Maginn EN, et al. PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells. Br J Cancer. 2011 Jan 18;104(2):281-9. [Content Brief]
- [2]. Mulligan JM, et al. Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines. Mol Pharmacol. 2006 Jul;70(1):60-70. [Content Brief]
Keywords
