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Cat. No.: HY-124624

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PBOX-15

PBOX-15 is a microtubule targeting agent. PBOX-15 induces apoptosis by promoting tubulin depolymerization in tumor cells.

For research use only. We do not sell to patients.

CAS No.: 354759-10-7
Formula: C₂₈H₁₉NO₃
Molecular Weight:417.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

PBOX-15 Chemical Structure

CAS No.: 354759-10-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PBOX-15 is a microtubule targeting agent. PBOX-15 induces apoptosis by promoting tubulin depolymerization in tumor cells^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	249 nM Compound: PNOX	Cytotoxicity against human A2780 cells after 48 hrs by MTT assay Cytotoxicity against human A2780 cells after 48 hrs by MTT assay	[PMID: 30448418]
Ca9-22	IC₅₀	0.083 μM Compound: PNOX	Cytotoxicity against human Ca9-22 cells after 72 hrs by MTT assay Cytotoxicity against human Ca9-22 cells after 72 hrs by MTT assay	[PMID: 30448418]
Ca9-22	IC₅₀	0.17 μM Compound: PNOX	Cytotoxicity against human Ca9-22 cells after 48 hrs by MTT assay Cytotoxicity against human Ca9-22 cells after 48 hrs by MTT assay	[PMID: 30448418]
Ca9-22	IC₅₀	0.21 μM Compound: PNOX	Cytotoxicity against human Ca9-22 cells after 24 hrs by MTT assay Cytotoxicity against human Ca9-22 cells after 24 hrs by MTT assay	[PMID: 30448418]
NCI-H929	IC₅₀	0.376 μM Compound: PNOX	Cytotoxicity against human NCI-H929 cells after 48 hrs by MTT assay Cytotoxicity against human NCI-H929 cells after 48 hrs by MTT assay	[PMID: 30448418]
NIH3T3	IC₅₀	126 nM Compound: PNOX	Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by MTT assay Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by MTT assay	[PMID: 30448418]
NIH3T3	IC₅₀	306 nM Compound: PNOX	Cytotoxicity against mouse NIH/3T3 cells harboring MDR G185 after 48 hrs by MTT assay Cytotoxicity against mouse NIH/3T3 cells harboring MDR G185 after 48 hrs by MTT assay	[PMID: 30448418]
SCC-4	IC₅₀	0.16 μM Compound: PNOX	Cytotoxicity against human SCC4 cells after 48 hrs by MTT assay Cytotoxicity against human SCC4 cells after 48 hrs by MTT assay	[PMID: 30448418]

Chemical Information

CAS No. 354759-10-7
Molecular Weight 417.46
Formula C₂₈H₁₉NO₃
SMILES

O=C(C)OC1=C(C2=C3C=CC=CC3=CC=C2)OC4=CC5=C(C=C4N6C=CC=C16)C=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Maginn EN, et al. PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells. Br J Cancer. 2011 Jan 18;104(2):281-9. [Content Brief]

[2]. Mulligan JM, et al. Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines. Mol Pharmacol. 2006 Jul;70(1):60-70. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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