35908-31-7
Chemical Structure
Inosine-5'-triphosphate trisodium salt
Synonym(s): ITP trisodium salt; Inosine triphosphate trisodium salt
- CAS No.: 35908-31-7
- Formula:C10H12N4Na3O14P3
- Molecular Weight:574.11
IUPAC Name: sodium ((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3,6-dihydro-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl hydrogen triphosphate
InChIKey: QRGLCGLOQVQVCS-MSQVLRTGSA-K
SMILES: O[C@@H]([C@H](N1C=NC2=C1NC=NC2=O)O3)[C@H](O)[C@H]3COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O
Biological Activity: Inosine-5'-triphosphate trisodium salt is a nucleotide analogue that acts on multiple G proteins and is widely used in G protein-related research. It can bind to the α -subunit of G proteins and participate in G protein-mediated signal transduction as a substitute for GTP. Its mechanism of action is to interact with the nucleotide-binding site of the G protein α -subunit, affecting the activity and function of G proteins. In the research field, it is mainly used to explore the role of the G protein signaling pathway in cellular physiological and pathological processes. For example, in HL-60 leukemia cells, its impact on G protein-mediated signal transduction can be studied[1][2][3][4].
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Inosine-5'-triphosphate trisodium salt | 99.09% | Inosine-5'-triphosphate trisodium salt is a nucleotide analogue that acts on multiple G proteins and is widely used in G protein-related research. It can bind to the α -subunit of G proteins and participate in G protein-mediated signal transduction as a substitute for GTP. Its mechanism of action is to interact with the nucleotide-binding site of the G protein α -subunit, affecting the activity and function of G proteins. In the research field, it is mainly used to explore the role of the G protein signaling pathway in cellular physiological and pathological processes. For example, in HL-60 leukemia cells, its impact on G protein-mediated signal transduction can be studied. | ||||||||||||||||||||
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Inosine-5'-triphosphate trisodium salt (Standard) | ≥98% | Inosine-5'-triphosphate (trisodium salt) (Standard) is the analytical standard of Inosine-5'-triphosphate (trisodium salt) (HY-W013706). This product is intended for research and analytical applications. Inosine-5'-triphosphate trisodium salt is a nucleotide analogue that acts on multiple G proteins and is widely used in G protein-related research. It can bind to the α -subunit of G proteins and participate in G protein-mediated signal transduction as a substitute for GTP. Its mechanism of action is to interact with the nucleotide-binding site of the G protein α -subunit, affecting the activity and function of G proteins. In the research field, it is mainly used to explore the role of the G protein signaling pathway in cellular physiological and pathological processes. For example, in HL-60 leukemia cells, its impact on G protein-mediated signal transduction can be studied. | ||||||||||||||||||||
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References
- [1]. Hanson RL, et al. Energy-transducing adenosine triphosphatase from Escherichia coli: purification, properties, and inhibition by antibody. J Bacteriol. 1973 May;114(2):772-81. [Content Brief]
- [2]. Pieper U, et al. The GTP-binding domain of McrB: more than just a variation on a common theme? J Mol Biol. 1999 Sep 24;292(3):547-56. [Content Brief]
- [3]. Klinker JF, et al. Functionally nonequivalent interactions of guanosine 5'-triphosphate, inosine 5'-triphosphate, and xanthosine 5'-triphosphate with the retinal G-protein, transducin, and with Gi-proteins in HL-60 leukemia cell membranes. Biochem Pharmacol. 1997 Sep 1;54(5):551-62. [Content Brief]
- [4]. Burnstock G, et al. Atropine resistant excitation of the urinary bladder: the possibility of transmission via nerves releasing a purine nucleotide. Br J Pharmacol. 1972 Mar;44(3):451-61. [Content Brief]
