376592-42-6
Chemical Structure
Totrombopag
- CAS No.: 376592-42-6
- Formula:C25H22N8O2
- Molecular Weight:466.49
IUPAC Name: (Z)-1-(3,4-dimethylphenyl)-4-(2-(2-hydroxy-3'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-3-yl)hydrazono)-3-methyl-1H-pyrazol-5(4H)-one
InChIKey: KWJKFQSAMABKBG-CYYJNZCTSA-N
SMILES: O=C1N(C2=CC=C(C)C(C)=C2)N=C(C1/N=N/C3=C(O)C(C4=CC(C5=NN=NN5)=CC=C4)=CC=C3)C
Biological Activity: Totrombopag is an orally effective thrombopoietin receptor (TpoR) agonist. By activating TpoR, Totrombopag initiates an intracellular signaling cascade mediated by JAK2 kinase and the transcription factor Stat5, a signaling process that is the primary mechanism regulating megakaryocyte growth and differentiation into platelets. Totrombopag can be used to study platelet production and megakaryocyte biology[1].
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Totrombopag | 99.00% | Totrombopag is an orally effective thrombopoietin receptor (TpoR) agonist. By activating TpoR, Totrombopag initiates an intracellular signaling cascade mediated by JAK2 kinase and the transcription factor Stat5, a signaling process that is the primary mechanism regulating megakaryocyte growth and differentiation into platelets. Totrombopag can be used to study platelet production and megakaryocyte biology. | ||||||||||||||||||||
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Keywords
