38090-53-8
38090-53-8
Chemical Structure
TACA
Synonym(s): trans-4-Aminocrotonic acid
- CAS No.: 38090-53-8
- Formula:C4H7NO2
- Molecular Weight:101.10
IUPAC Name: (E)-4-aminobut-2-enoic acid
InChIKey: FMKJUUQOYOHLTF-OWOJBTEDSA-N
SMILES: O=C(O)/C=C/CN
Biological Activity: TACA (trans-4-Aminocrotonic acid) is a potent agonist of GABAA and GABAC receptors (KD= 0.6 μM). TACA also is GABA uptake inhibitor and substrate for GABA-T. TACA produces late biphasic responses in the MPG neurons[1][2][3].
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TACA | 99.33% | TACA (trans-4-Aminocrotonic acid) is a potent agonist of GABAA and GABAC receptors (KD= 0.6 μM). TACA also is GABA uptake inhibitor and substrate for GABA-T. TACA produces late biphasic responses in the MPG neurons. | ||||||||||||||||||||
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TACA (Standard) | ≥98% | TACA (Standard) is the analytical standard of TACA (HY-100800). This product is intended for research and analytical applications. TACA (trans-4-Aminocrotonic acid) is a potent agonist of GABAA and GABAC receptors (KD= 0.6 μM). TACA also is GABA uptake inhibitor and substrate for GABA-T. TACA produces late biphasic responses in the MPG neurons. | ||||||||||||||||||||
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References
- [1]. Chebib M, et al. Analogues of gamma-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. Br J Pharmacol. 1997;122(8):1551-1560. [Content Brief]
- [2]. Akasu T, et al. Role of GABAA and GABAC receptors in the biphasic GABA responses in neurons of the rat major pelvic ganglia. J Neurophysiol. 1999;82(3):1489-1496. [Content Brief]
- [3]. Johnston GA, et al. Cis- and trans-4-aminocrotonic acid as GABA analogues of restricted conformation. J Neurochem. 1975;24(1):157-160. [Content Brief]
Keywords
