TACA (Synonyms: trans-4-Aminocrotonic acid)

Cat. No.: HY-100800 Purity: 99.33%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

TACA (trans-4-Aminocrotonic acid) is a potent agonist of GABA_A and GABA_C receptors (K_D= 0.6 μM). TACA also is GABA uptake inhibitor and substrate for GABA-T. TACA produces late biphasic responses in the MPG neurons.

For research use only. We do not sell to patients.

TACA Chemical Structure

CAS No. : 38090-53-8

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 88	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 88	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 670	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Biological Activity
Purity & Documentation
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Description

IC₅₀ & Target

K_D: 0.6 μM (GABA_C)^[1].

In Vivo

TACA is a potent competitive inhibitor of GABA uptake in rat brain slices and thus is possibly a substrate for the GABA uptake system^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

101.10

Formula

C₄H₇NO₂

CAS No.

38090-53-8

Appearance

Solid

Color

Off-white to yellow

SMILES

O=C(O)/C=C/CN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 20 mg/mL (197.82 mM; ultrasonic and warming and heat to 60°C)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	9.8912 mL	49.4560 mL	98.9120 mL
5 mM	1.9782 mL	9.8912 mL	19.7824 mL
10 mM	0.9891 mL	4.9456 mL	9.8912 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 4 mg/mL (39.56 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.33%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (242 KB) HNMR (232 KB) LCMS (268 KB) Elemental Analysis Report (101 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	9.8912 mL	49.4560 mL	98.9120 mL	247.2799 mL
	5 mM	1.9782 mL	9.8912 mL	19.7824 mL	49.4560 mL
	10 mM	0.9891 mL	4.9456 mL	9.8912 mL	24.7280 mL
	15 mM	0.6594 mL	3.2971 mL	6.5941 mL	16.4853 mL
	20 mM	0.4946 mL	2.4728 mL	4.9456 mL	12.3640 mL
	25 mM	0.3956 mL	1.9782 mL	3.9565 mL	9.8912 mL
	30 mM	0.3297 mL	1.6485 mL	3.2971 mL	8.2427 mL
	40 mM	0.2473 mL	1.2364 mL	2.4728 mL	6.1820 mL
	50 mM	0.1978 mL	0.9891 mL	1.9782 mL	4.9456 mL
	60 mM	0.1649 mL	0.8243 mL	1.6485 mL	4.1213 mL
	80 mM	0.1236 mL	0.6182 mL	1.2364 mL	3.0910 mL
	100 mM	0.0989 mL	0.4946 mL	0.9891 mL	2.4728 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TACA38090-53-8trans-4-Aminocrotonic acidInhibitorinhibitorinhibit

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