38115-21-8
Chemical Structure
Desacetyl cephapirin
- CAS No.: 38115-21-8
- Formula:C15H15N3O5S2
- Molecular Weight:381.42
IUPAC Name: (6R,7R)-3-(hydroxymethyl)-8-oxo-7-(2-(pyridin-4-ylthio)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
InChIKey: IOFHZPVEQXTSQW-BXUZGUMPSA-N
SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(CSC=3C=CN=CC3)=O)C2=O)(SCC1CO)[H]
Biological Activity: Desacetyl cephapirin is the active metabolite of Cephapirin (HY-A0153). Desacetyl cephapirin retains bactericidal activity by disrupting bacterial cell wall synthesis, but exhibits reduced antimicrobial activity, longer in vivo residual time, and high tissue retention. Desacetyl cephapirin can be used in studies related to Gram-positive bacterial infections[1][2].
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Desacetyl cephapirin | Desacetyl cephapirin is the active metabolite of Cephapirin (HY-A0153). Desacetyl cephapirin retains bactericidal activity by disrupting bacterial cell wall synthesis, but exhibits reduced antimicrobial activity, longer in vivo residual time, and high tissue retention. Desacetyl cephapirin can be used in studies related to Gram-positive bacterial infections. | |||||||||||||||||||||
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- [1]. Cortinhas CS, et al. Minimum inhibitory concentrations of cephalosporin compounds and their active metabolites for selected mastitis pathogens. American journal of veterinary research. 2013 May;74(5):683-90. [Content Brief]
- [2]. Moats WA, et al. Conversion of cephapirin to deacetylcephapirin in milk and tissues of treated animals. Journal of agricultural and food chemistry. 2000 Feb;48(2):498-502. [Content Brief]
Keywords
