42061-33-6
![D[LEU4,LYS8]-VP Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-p1163.gif "D[LEU4,LYS8]-VP Chemical Structure")
42061-33-6
Chemical Structure
D[LEU4,LYS8]-VP
- CAS No.: 42061-33-6
- Formula:C47H67N11O11S2
- Molecular Weight:1026.23
SMILES: [{Mpa}-YFLNCPKG-NH2 (Disulfide bridge:Mpa1-Cys6)]
Biological Activity: D[LEU4,LYS8]-VP is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4,LYS8]-VP has weak antidiuretic, vasopressor, and in vitro oxytocic activities[1][2].
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D[LEU4,LYS8]-VP | D[LEU4,LYS8]-VP is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4,LYS8]-VP has weak antidiuretic, vasopressor, and in vitro oxytocic activities. | |||||||||||||||||||||
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References
- [1]. Ana P, et, al. Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology. 2007 Sep; 148(9): 4136-46. [Content Brief]
- [2]. Ana P, et, al. Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8. J Med Chem. 2007 Feb 22; 50(4): 835-47. [Content Brief]
Keywords
