466-75-1
466-75-1
Chemical Structure
Haemanthamine
- CAS 番号: 466-75-1
- Formula:C17H19NO4
- Molecular Weight:301.34
IUPAC Name: (3S,4aS,5S,11bS,12R)-3-methoxy-4,4a-dihydro-3H,6H-11b,5-ethano[1,3]dioxolo[4,5-j]phenanthridin-12-ol
InChIKey: YGPRSGKVLATIHT-HSHDSVGOSA-N
SMILES: O[C@@H](C1)[C@@]2(C=C3)C4=CC(OCO5)=C5C=C4C[N@@]1[C@@]2([H])C[C@@H]3OC
Biological Activity: Haemanthamine is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities[1][2].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Haemanthamine | 95.10% | Haemanthamine is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities. | ||||||||||||||||||||
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Buphanidrine | Buphanidrine is an acetylcholinesterase (AChE) inhibitor with an IC50 of 52.8 μM. Buphanidrine can be extracted from Brunsvigia josephinae and has potential applications in Alzheimer's disease research. | |||||||||||||||||||||
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Lycorine (Standard) | 99.54% | Lycorine (Standard) is the analytical standard of Lycorine. This product is intended for research and analytical applications. Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription. Lycorine is also a melanoma vasculogenic inhibitor. Lycorine can be used for the study of prostate cancer and metabolic diseases. | ||||||||||||||||||||
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Lycorine hydrochloride (Standard) | ≥98% | Lycorine (hydrochloride) (Standard) is the analytical standard of Lycorine (hydrochloride). This product is intended for research and analytical applications. Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radiata (L’Her.) Herb. and is also a melanoma vasculogenic inhibitor and has anti-tumor activity. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC50 of 1.2 μM). | ||||||||||||||||||||
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Acetylcaranine | Acetylcaranine is a alkaloids that can isolated from bulbs of Amaryllis belladonna Steud. Acetylcaranine shows exhibited strong antiplasmodial activity and anticancer activity. | |||||||||||||||||||||
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Coccinine | Coccinine ((-)-Coccinine) is a weak inhibitor of SERT (IC50: 196.3 μM; Ki: 106.8 μM) and P-gp (IC50: 0.96 mM). Coccinine exhibits significant anti-tumor activity against various cancer cell lines, such as breast cancer (MCF7, Hs578T, MDA-MB-231), colon cancer (HCT-15), and lung cancer (A549). Coccinine can be used in the research of tumors and neurological diseases. | |||||||||||||||||||||
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Powelline | Powelline is a natural alkaloid. | |||||||||||||||||||||
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Macowine | Macowine is a natural alkaloid. | |||||||||||||||||||||
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Pancracine | Pancracine is an alkaloid. Pancracine upregulates p27, phosphorylated p38 MAPK and phosphorylated p53, while downregulating phosphorylated Akt and phosphorylated Rb. Pancracine induces G1 cell cycle arrest and Apoptosis in cells. Pancracine inhibits the replication of pseudotyped HIV-1 and Dengue virus. Pancracine can be used in research related to lung adenocarcinoma, acute lymphoblastic leukemia, cutaneous epidermoid carcinoma, human immunodeficiency virus infection and dengue virus infection. | |||||||||||||||||||||
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Crinine | Crinine is a natural alkaloid. | |||||||||||||||||||||
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Tazettine | Tazettine is an alkaloid with low cytotoxicity to mammalian cell lines (CC50 >100 μg/mL). | |||||||||||||||||||||
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References
- [1]. Pellegrino S, et al. The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth. Structure. 2018 Mar 6;26(3):416-425.e4. [Content Brief]
- [2]. Seifrtová M, et al. Haemanthamine alters sodium butyrate-induced histone acetylation, p21WAF1/Cip1 expression, Chk1 and Chk2 activation and leads to increased growth inhibition and death in A2780 ovarian cancer cells. Phytomedicine. 2017 Nov 15;35:1-10. [Content Brief]
