468719-53-1
Chemical Structure
AFP464
Synonym(s): NSC710464
- CAS No.: 468719-53-1
- Formula:C24H31F3N4O9S2
- Molecular Weight:640.65
IUPAC Name: (S)-2,6-diamino-N-(4-(5-amino-6,8-difluoro-7-methyl-4-oxo-4H-chromen-2-yl)-2-fluorophenyl)hexanamide methanesulfonate
InChIKey: FDQJDUBLCBZBCQ-GXKRWWSZSA-N
SMILES: CS(=O)(O)=O.FC1=C2C(C(C=C(C3=CC(F)=C(C=C3)NC([C@@H](N)CCCCN)=O)O2)=O)=C(C(F)=C1C)N.CS(=O)(O)=O
Biological Activity: AFP464 (NSC710464) is a prodrug of Aminoflavone (HY-132974) and an agonist of the aryl hydrocarbon receptor (AhR). AFP464 downregulates the expression of α6-integrin (α6-integrin), inhibits breast tumor growth, reduces the population of tumor-initiating cells, disrupts mammosphere structure, induces the formation of mucin lake clusters, triggers DNA damage, and exerts antiproliferative activity. AFP464 is rapidly converted to Aminoflavone by nonspecific esterases in plasma and cell culture media. AFP464 is applicable to research related to breast cancer[1][2].
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AFP464 | AFP464 (NSC710464) is a prodrug of Aminoflavone (HY-132974) and an agonist of the aryl hydrocarbon receptor (AhR). AFP464 downregulates the expression of α6-integrin (α6-integrin), inhibits breast tumor growth, reduces the population of tumor-initiating cells, disrupts mammosphere structure, induces the formation of mucin lake clusters, triggers DNA damage, and exerts antiproliferative activity. AFP464 is rapidly converted to Aminoflavone by nonspecific esterases in plasma and cell culture media. AFP464 is applicable to research related to breast cancer. | |||||||||||||||||||||
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- [1]. Brantley E, et al. AhR ligand Aminoflavone inhibits α6-integrin expression and breast cancer sphere-initiating capacity. Cancer Lett. 2016;376(1):53-61. [Content Brief]
- [2]. Stark K, et al. Reactivation of estrogen receptor α by vorinostat sensitizes mesenchymal-like triple-negative breast cancer to aminoflavone, a ligand of the aryl hydrocarbon receptor. PLoS One. 2013;8(9):e74525. Published 2013 Sep 13. [Content Brief]
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