50405-58-8
50405-58-8
Chemical Structure
TC-E 5008
- CAS No.: 50405-58-8
- Formula:C13H13NO2
- Molecular Weight:215.25
IUPAC Name: 6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one
InChIKey: AVLZAVSZOAQKRC-UHFFFAOYSA-N
SMILES: ON1C(CC2=CC=CC=C2)=CC(C)=CC1=O
Biological Activity: TC-E 5008 is a potent mutant IDH1 inhibitor with Ki values of 190 nM and 120 nM for R132H and R132C IDH1 mutants, respectively. TC-E 5008 exhibits very weak activity against WT-IDH1 with a Ki value of 12.3 μM. TC-E 5008 has anti-proliferative activity on multiple ER positive breast cancer cell lines[1][2].
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TC-E 5008 | TC-E 5008 is a potent mutant IDH1 inhibitor with Ki values of 190 nM and 120 nM for R132H and R132C IDH1 mutants, respectively. TC-E 5008 exhibits very weak activity against WT-IDH1 with a Ki value of 12.3 μM. TC-E 5008 has anti-proliferative activity on multiple ER positive breast cancer cell lines. | |||||||||||||||||||||
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References
Keywords
