50440-30-7
Chemical Structure
T3Inh-1
- CAS No.: 50440-30-7
- Formula:C27H20N6O3
- Molecular Weight:476.49
IUPAC Name: 4-((6-nitroquinolin-4-yl)amino)-N-(4-(pyridin-4-ylamino)phenyl)benzamide
InChIKey: KUBNLSZSAIOAMS-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(NC2=CC=NC=C2)C=C1)C3=CC=C(NC4=CC=NC5=CC=C([N+]([O-])=O)C=C45)C=C3
Biological Activity: T3Inh-1 is a potent and selective inhibitor of ppGalNAc-T3 (IC50=7 μM). T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects. T3Inh-1 also prevents breast cancer cells. The enzyme ppGalNAc-T3 is implicated in at least two medically important pathways: cancer metastasis and stabilization of FGF23 (regulates phosphate levels in the bloodstream)[1].
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T3Inh-1 | 98.10% | T3Inh-1 is a potent and selective inhibitor of ppGalNAc-T3 (IC50=7 μM). T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects. T3Inh-1 also prevents breast cancer cells. The enzyme ppGalNAc-T3 is implicated in at least two medically important pathways: cancer metastasis and stabilization of FGF23 (regulates phosphate levels in the bloodstream). | ||||||||||||||||||||
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Keywords
