54354-62-0
Chemical Structure
Decarine
Synonym(s): Rutaceline
- CAS No.: 54354-62-0
- Formula:C19H13NO4
- Molecular Weight:319.31
IUPAC Name: 1-methoxy-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-2-ol
InChIKey: GJJFWGQGJJGJEO-UHFFFAOYSA-N
SMILES: OC1=C(OC)C2=CN=C3C(C(C=CC3=C2C=C1)=C4)=CC5=C4OCO5
Biological Activity: Decarine (Rutaceline) is a benzophenanthridine alkaloid found in Zanthoxylum species. Decarinewith shows anti-inflammatory, antimycobacterial, and anti-HIV activity. Decarine inhibits NO, TNF-α, IL-1β, IL-6, and IL-8 production in inflammatory cell models. Decarine inhibits growth of Mycobacterium tuberculosis strains, reduces intracellular Mycobacterium tuberculosis survival, and shows low cytotoxicity toward human macrophages. Decarine inhibits HIV replication in acutely infected lymphocytes. Decarine can be used for the researches of inflammation, tuberculosis, and HIV infection[1][2][3].
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Decarine | Decarine (Rutaceline) is a benzophenanthridine alkaloid found in Zanthoxylum species. Decarinewith shows anti-inflammatory, antimycobacterial, and anti-HIV activity. Decarine inhibits NO, TNF-α, IL-1β, IL-6, and IL-8 production in inflammatory cell models. Decarine inhibits growth of Mycobacterium tuberculosis strains, reduces intracellular Mycobacterium tuberculosis survival, and shows low cytotoxicity toward human macrophages. Decarine inhibits HIV replication in acutely infected lymphocytes. Decarine can be used for the researches of inflammation, tuberculosis, and HIV infection. | |||||||||||||||||||||
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- [1]. Zhang HL, et al. Chemical constituents and anti-inflammatory activities of Maqian (Zanthoxylum myriacanthum var. pubescens) bark extracts. Sci Rep. 2017;7:45805. Published 2017 Apr 6. [Content Brief]
- [2]. Luo X, et al. Zanthoxylum capense constituents with antimycobacterial activity against Mycobacterium tuberculosis in vitro and ex vivo within human macrophages. J Ethnopharmacol. 2013;146(1):417-422. [Content Brief]
- [3]. Cheng MJ, et al. Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides. Bioorg Med Chem. 2005;13(21):5915-5920. [Content Brief]
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