551909-15-0
551909-15-0
Chemical Structure
RTICBM-189
- CAS No.: 551909-15-0
- Formula:C15H14Cl2N2O
- Molecular Weight:309.19
IUPAC Name: 1-(3-chlorophenethyl)-3-(4-chlorophenyl)urea
InChIKey: PPKIPROVSKBYAT-UHFFFAOYSA-N
SMILES: O=C(NCCC1=CC(Cl)=CC=C1)NC2=CC=C(C=C2)Cl
Biological Activity: RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectively. RTICBM-189 significantly and selectively attenuates the reinstatement of the addictive agent-seeking behavior in rats[1].
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RTICBM-189 | 99.73% | RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectively. RTICBM-189 significantly and selectively attenuates the reinstatement of the addictive agent-seeking behavior in rats. | ||||||||||||||||||||
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References
- [1]. Nguyen T, et al. Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior [published online ahead of print, 2021 Dec 20]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01432. [Content Brief]
Keywords
