56-89-3
56-89-3
Chemical Structure
L-Cystine
- CAS No.: 56-89-3
- Formula:C6H12N2O4S2
- Molecular Weight:240.30
IUPAC Name: (2R,2'R)-3,3'-disulfanediylbis(2-aminopropanoic acid)
InChIKey: LEVWYRKDKASIDU-IMJSIDKUSA-N
SMILES: N[C@@H](CSSC[C@@H](C(O)=O)N)C(O)=O
Biological Activity: L-Cystine is an orally active extracellular form of L-Cysteine (HY-Y0337), occurring in proteins of plants and animals. L-Cystine elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-cystine reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine is promising for research of cystinuria and kidney stones[1][2][3][4][5][6]
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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L-Cystine | 99.84% | L-Cystine is an orally active extracellular form of L-Cysteine (HY-Y0337), occurring in proteins of plants and animals. L-Cystine elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-cystine reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine is promising for research of cystinuria and kidney stones | ||||||||||||||||||||
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L-Cystine (Standard) | 96.68% | L-Cystine (Standard) is the analytical standard of L-Cystine. This product is intended for research and analytical applications. L-Cystine, the extracellular form of L-Cysteine (HY-Y0337), is a nutritionally dispensable semiessential sulfur-containing amino acid, occurring in proteins of plants and animals. L-Cystine induces Nrf2 protein elevation in a Keap1 (HY-P75897)-dependent manner and activates Nrf2 transcription factor. L-cystine can elicit cytoprotection by reducing ROS generation and protecting against oxidant- or doxorubicin-induced apoptosis. The reduced reabsorption of L-Cystine in renal tubules and its poor solubility in urine are the important causes of cystine precipitation and cystine crystal formation eventually leading to kidney stones. L-Cystine combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine is promising for research of cystinuria and cystinosis | ||||||||||||||||||||
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L-Cystine-3,3'-13C2 | 99.0% | L-Cystine-3,3'-13C2 is the 13C labeled L-Cystine. L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes. | ||||||||||||||||||||
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L-Cystine-15N2 | 99.27% | L-Cystine-15N2 is the 15N-labeled L-Cystine. L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes. | ||||||||||||||||||||
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L-Cystine-13C6,15N2 | 98.4% | L-Cystine-13C6,15N2 is the 13C- and 15N-labeled L-Cystine (HY-N0394). L-Cystine is an orally active extracellular form of L-Cysteine (HY-Y0337), occurring in proteins of plants and animals. L-Cystine elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-cystine reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine is promising for research of cystinuria and kidney stones. | ||||||||||||||||||||
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L-Cystine-d4 | 98.0% | L-Cystine-d4 is the deuterium labeled L-Cystine. L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes. | ||||||||||||||||||||
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Methylmalonic acid-d3 | 98.91% | Methylmalonic acid-d3 is the deuterium labeled Methylmalonic acid. Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer. | ||||||||||||||||||||
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Djenkolic acid | 98.0% | Djenkolic acid is a sulfur-containing amino acid. Djenkolic acid can be isolated from the djenkol beans of the Southeast Asian plant Archidendron jiringa. Djenkolic acid de-inhibits the SO42- uptake system in Pseudomonas fluorescens. Djenkolic acid causes supersaturation of the urinary system with djenkolic acid crystals, leading to urinary tract obstruction and acute kidney injury. | ||||||||||||||||||||
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Djenkolic acid (Standard) | ≥98% | Djenkolic acid (Standard) is the analytical standard of Djenkolic acid (HY-125923). This product is intended for research and analytical applications. Djenkolic acid is a sulfur-containing amino acid. Djenkolic acid can be isolated from the djenkol beans of the Southeast Asian plant Archidendron jiringa. Djenkolic acid de-inhibits the SO42- uptake system in Pseudomonas fluorescens. Djenkolic acid causes supersaturation of the urinary system with djenkolic acid crystals, leading to urinary tract obstruction and acute kidney injury. | ||||||||||||||||||||
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DL/meso-Lanthionine | DL/meso-Lanthionine is a mixture of the racemic mixture (DL-) and meso- isomers of Lanthionine. Lanthionine is a non-protein amino acid composed of two alanine residues cross-linked by a thioether bond and is a structural component of the bacterial cell wall. | |||||||||||||||||||||
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D-Cystine | 98.0% | D-Cystine is the D-enantiomer of L-Cystine. D-Cystine inhibits L-aspartate-β-semialdehyde dehydrogenase (ASADH) from Escherichia coli. | ||||||||||||||||||||
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L-Cystine monohydrochloride | L-Cystine monohydrochloride is an amino acid. L-Cystine is converted to L-Cysteine in the body. Moreover, L-Cystine/L-Cysteine conversion system is a channel on the cell membrane, which can maintain the internal REDOX homeostasis of E. coli. | |||||||||||||||||||||
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L-Cystathionine | 99.91% | L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection. | ||||||||||||||||||||
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DL-Cystathionine | 97.38% | DL-Cystathionine is a mixture of 4 isomers of cystathionine and allocystathionine. DL-Cystathionine also is an intermediate in the biosynthesis of amino acid cysteine. DL-Cystathionine serves as a standard for quantifying tissue cystathionine. | ||||||||||||||||||||
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DL-Cystine | 95.0% | DL-Cystine is a cysteine derivative. | ||||||||||||||||||||
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DL-Cystine-d4 | 99.8% | DL-Cystine-d4 is the deuterium labeled DL-Cystine (HY-W013940). DL-Cystine is a cysteine derivative. | ||||||||||||||||||||
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DL-Cystine-d6 | 99.96% | DL-Cystine-d6 is the deuterium labeled DL-Cystine (HY-W013940). DL-Cystine is a cysteine derivative. | ||||||||||||||||||||
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DL-Lanthionine | 99.46% | DL-Lanthionine is a distinctive amino acid and a monosulfide counterpart to cystine, playing a vital role as a component of peptide antibiotics known as lantiobiotics, which encompass well-known examples such as nisin and subtilin. | ||||||||||||||||||||
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References
- [1]. Abdullah M, et al. Extracellular Concentration of L-Cystine Determines the Sensitivity to System xc- Inhibitors[J]. Biomol Ther (Seoul). 2022 Mar 1;30(2):184-190. [Content Brief]
- [2]. Kurihara S, et al. Enhancement of antigen-specific immunoglobulin G production in mice by co-administration of L-cystine and L-theanine[J]. J Vet Med Sci. 2007 Dec;69(12):1263-70. [Content Brief]
- [3]. Dominique Bazin,et al. Cystinuria and cystinosis are usually related to L-cystine: is this really the case for cystinosis? A physicochemical investigation at micrometre and nanometre scale. Comptes Rendus. Chimie, Volume 25 (2022) no. S1, pp. 489-502.
- [4]. Greth WE, et al. Cellular accumulation of L-cystine in rat kidney cortex in vivo[J]. J Clin Invest. 1973 Feb;52(2):454-62. [Content Brief]
- [5]. Ohtsu I, et al. Uptake of L-cystine via an ABC transporter contributes defense of oxidative stress in the L-cystine export-dependent manner in Escherichia coli. PLoS One. 2015 Apr 2;10(3):e0120619. [Content Brief]
- [6]. Dai W, et al. Fresh Medium or L-Cystine as an Effective Nrf2 Inducer for Cytoprotection in Cell Culture[J]. Cells. 2023 Jan 12;12(2):291. [Content Brief]
