566872-15-9
Chemical Structure
STE-MEK1(13)
Synonym(s): Ste-MPKKKPTPIQLNP-NH₂; ERK Activation Inhibitor Peptide
- CAS No.: 566872-15-9
- Formula:C86H153N19O17S
- Molecular Weight:1757.32
InChIKey: JTGVJZGFSQPZSN-ANGLJYEKSA-N
SMILES: O=C(N(CCC1)[C@@H]1C(N[C@@H]([C@H](O)C)C(N(CCC2)[C@@H]2C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N(CCC3)[C@@H]3C(N)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCC4)N4C([C@H](CCSC)NC(CCCCCCCCCCCCCCCCC)=O)=O)=O)=O)=O
Biological Activity: STE-MEK1(13) (Ste-MPKKKPTPIQLNP-NH ) is a cell permeable ERK1/2 inhibitor (IC50: 13-30 μM). STE-MEK1(13) inhibits ERK1/2 phosphorylation[1][2].
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STE-MEK1(13) | STE-MEK1(13) (Ste-MPKKKPTPIQLNP-NH ) is a cell permeable ERK1/2 inhibitor (IC50: 13-30 μM). STE-MEK1(13) inhibits ERK1/2 phosphorylation. | |||||||||||||||||||||
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- [1]. Li G, et al. A novel cellular survival factor--the B2 subunit of vacuolar H+-ATPase inhibits apoptosis. Cell Death Differ. 2006 Dec;13(12):2109-17. [Content Brief]
- [2]. Whiteman M, et al. Peroxynitrite-modified collagen-II induces p38/ERK and NF-kappaB-dependent synthesis of prostaglandin E2 and nitric oxide in chondrogenically differentiated mesenchymal progenitor cells. Osteoarthritis Cartilage. 2006 May;14(5):460-70. [Content Brief]
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