60462-09-1
Chemical Structure
Cassialoin
- CAS No.: 60462-09-1
- Formula:C21H22O9
- Molecular Weight:418.39
InChIKey: UQFYMIDDRRJKBM-XFDYOUIBSA-N
SMILES: O=C1C2=C(C=CC=C2O)C(O)([C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C4=CC(C)=CC(O)=C14
Biological Activity: Cassialoin is an orally active anthrone-C-glucoside natural product with antitumor activity, which is found in the heartwood of Cassia garrettiana. Cassialoin is metabolized to the active substance Chrysophanol‑9‑anthrone. Cassialoin does not directly inhibit the activities of VEGFR‑2 and MMP‑9 in vitro, nor does it directly inhibit vascular lumen formation and cell migration in vitro. Cassialoin increases the number of IFN-γ-positive CD8+ T cells and natural killer cells in the small intestine or spleen, and enhances IFN-γ production by splenocytes induced by Concanavalin A (HY-P2149). Cassialoin inhibits tumor growth and peritoneal invasion in colon cancer xenograft models. Cassialoin can be used for research on colon cancer[1][2].
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Cassialoin | Cassialoin is an orally active anthrone-C-glucoside natural product with antitumor activity, which is found in the heartwood of Cassia garrettiana. Cassialoin is metabolized to the active substance Chrysophanol‑9‑anthrone. Cassialoin does not directly inhibit the activities of VEGFR‑2 and MMP‑9 in vitro, nor does it directly inhibit vascular lumen formation and cell migration in vitro. Cassialoin increases the number of IFN-γ-positive CD8+ T cells and natural killer cells in the small intestine or spleen, and enhances IFN-γ production by splenocytes induced by Concanavalin A (HY-P2149). Cassialoin inhibits tumor growth and peritoneal invasion in colon cancer xenograft models. Cassialoin can be used for research on colon cancer. | |||||||||||||||||||||
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References
- [1]. Hata K, et al. The Structure of Cassialoin, a New Anthrone C-Glycoside from the Heartwood of Cassia garrettiana CRAIB. Chemical and Pharmaceutical Bulletin, 1976, 24(7):1688‑1689.
- [2]. Kimura Y, et al. Antitumor and antimetastatic actions of anthrone-C-glucoside, cassialoin isolated from Cassia garrettiana heartwood in colon 26-bearing mice. Cancer Sci. 2008 Nov;99(11):2336-48.
