617720-02-2
617720-02-2
Chemical Structure
HT-0712
- CAS No.: 617720-02-2
- Formula:C25H31NO3
- Molecular Weight:393.52
IUPAC Name: (3S,5S)-5-(3-(cyclopentyloxy)-4-methoxyphenyl)-3-(3-methylbenzyl)piperidin-2-one
InChIKey: ABEJDMOBAFLQNJ-NHCUHLMSSA-N
SMILES: COC1=C(C=C([C@@H]2C[C@H](C(NC2)=O)CC3=CC(C)=CC=C3)C=C1)OC4CCCC4
Biological Activity: HT-0712 is a Phosphodiesterase Type 4 (PDE4) inhibitor. HT-0712 enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia[1][2].
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HT-0712 | HT-0712 is a Phosphodiesterase Type 4 (PDE4) inhibitor. HT-0712 enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia. | |||||||||||||||||||||
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References
- [1]. Marco Peters, et al. The PDE4 inhibitor HT-0712 improves hippocampus-dependent memory in aged mice. Neuropsychopharmacology. 2014 Dec;39(13):2938-48.
- [2]. Erin MacDonald, et al. A novel phosphodiesterase type 4 inhibitor, HT-0712, enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia. Neurorehabil Neural Repair. 2007 Nov-Dec;21(6):486-96. [Content Brief]
Keywords
