65718-85-6
Chemical Structure
Dihydrocitrinone
- CAS No.: 65718-85-6
- Formula:C13H14O6
- Molecular Weight:266.25
IUPAC Name: (3R,4S)-6,8-dihydroxy-3,4,5-trimethyl-1-oxoisochromane-7-carboxylic acid
InChIKey: VVVMDYGNIVXIIG-INEUFUBQSA-N
SMILES: OC1=C2C(=C(C)C(O)=C1C(O)=O)[C@H](C)[C@@H](C)OC2=O
Biological Activity: Dihydrocitrinone is a polyketide secondary metabolite and the major urinary metabolite of citrinin, which can be isolated from Aspergillus strains derived from the rhizosphere soil of date palms. Dihydrocitrinone exerts independent toxic effects in renal cell cultures and zebrafish embryo models, enhances the toxic effects of Ochratoxin A through additive or synergistic actions, and increases the level of miR-731 in zebrafish embryos when acting in combination with Ochratoxin A[1][2].
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Dihydrocitrinone | Dihydrocitrinone is a polyketide secondary metabolite and the major urinary metabolite of citrinin, which can be isolated from Aspergillus strains derived from the rhizosphere soil of date palms. Dihydrocitrinone exerts independent toxic effects in renal cell cultures and zebrafish embryo models, enhances the toxic effects of Ochratoxin A through additive or synergistic actions, and increases the level of miR-731 in zebrafish embryos when acting in combination with Ochratoxin A. | |||||||||||||||||||||
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- [1]. Orfali R, et al. Secondary metabolites from the Aspergillus sp. in the rhizosphere soil of Phoenix dactylifera (Palm tree). BMC Chem. 2019 Aug 7;13(1):103. [Content Brief]
- [2]. Csenki Z, et al. The individual and combined effects of ochratoxin A with citrinin and their metabolites (ochratoxin B, ochratoxin C, and dihydrocitrinone) on 2D/3D cell cultures, and zebrafish embryo models. Food Chem Toxicol. 2021 Dec;158:112674. [Content Brief]
Keywords
