667905-37-5
Chemical Structure
GW 833972A free base
- CAS No.: 667905-37-5
- Formula:C18H13ClF3N5O
- Molecular Weight:407.78
IUPAC Name: 2-((3-chlorophenyl)amino)-N-(pyridin-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide
InChIKey: HLCPJLIYGNWTAI-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C(NC2=CC(Cl)=CC=C2)N=C1C(F)(F)F)NCC3=CC=NC=C3
Biological Activity: GW 833972A free base is a selective CB₂ receptor agonist with pEC₅₀ of the human CB₂ receptor for GW 833972A free base of 7.3, and its selectivity for the CB₂ receptor is approximately 1000 times higher than that for the CB₁ receptor. GW 833972A free base inhibits induced neuronal depolarization and suppresses coughing caused by citric acid in guinea pig models. GW 833972A free base can be used for the study of chronic cough[1].
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GW 833972A free base | GW 833972A free base is a selective CB₂ receptor agonist with pEC₅₀ of the human CB₂ receptor for GW 833972A free base of 7.3, and its selectivity for the CB₂ receptor is approximately 1000 times higher than that for the CB₁ receptor. GW 833972A free base inhibits induced neuronal depolarization and suppresses coughing caused by citric acid in guinea pig models. GW 833972A free base can be used for the study of chronic cough. | |||||||||||||||||||||
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Keywords
