70161-09-0
Chemical Structure
Democonazole
- CAS No.: 70161-09-0
- Formula:C19H15Cl3N2O2
- Molecular Weight:409.69
IUPAC Name: (E)-1-(2-(2-(4-chlorophenoxy)ethoxy)-2-(2,4-dichlorophenyl)vinyl)-1H-imidazole
InChIKey: ABVFVJRTKMVJMV-XDHOZWIPSA-N
SMILES: C(=C/N1C=CN=C1)(\OCCOC2=CC=C(Cl)C=C2)/C3=C(Cl)C=C(Cl)C=C3
Biological Activity: Democonazole is an imidazole antifungal agent that blocks ergosterol synthesis by inhibiting CYP450 14α-lanosterol demethylase (CYP51), thereby disrupting the integrity and fluidity of fungal cell membranes. Democonazole is lipophilic, which enhances its ability to penetrate fungal cell membranes and inhibit ergosterol synthesis. Democonazole can be used in studies related to fungal infections[1][2].
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Democonazole | Democonazole is an imidazole antifungal agent that blocks ergosterol synthesis by inhibiting CYP450 14α-lanosterol demethylase (CYP51), thereby disrupting the integrity and fluidity of fungal cell membranes. Democonazole is lipophilic, which enhances its ability to penetrate fungal cell membranes and inhibit ergosterol synthesis. Democonazole can be used in studies related to fungal infections. | |||||||||||||||||||||
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References
- [1]. Markham PN, et al. ANTIFUNGAL COMPOUNDS AND USES THEREFOR. International Application No. PCT/US01/46938, published as WO 02/36203 A2, 10 May 2002.
- [2]. Marzo A, et al. Gas chromatographic evaluation of the antimycotic democonazole for pharmacokinetic and bioavailability studies in man and animals. Arzneimittelforschung. 1986 Oct;36(10):1440-1.
