7290-03-1
7290-03-1
Chemical Structure
Erysodine
- CAS No.: 7290-03-1
- Formula:C18H21NO3
- Molecular Weight:299.37
IUPAC Name: (2R,13bS)-2,12-dimethoxy-2,6,8,9-tetrahydro-1H-indolo[7a,1-a]isoquinolin-11-ol
InChIKey: BDIVMECULLJBMU-KSSFIOAISA-N
SMILES: O(C)[C@@H]1C[C@]23C=4C(CCN2CC=C3C=C1)=CC(O)=C(OC)C4
Biological Activity: Erysodine is a blood-brain barrier-permeable nicotinic acetylcholine receptor (nAChR) ligand with high affinity for α4β2 nAChR, Ki = 5 nM, and it blocks nicotine-induced dopamine release and behavioral effects through competitive inhibition. Erysodine is useful for studies on alcohol dependence[1][2][3][4].
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Erysodine | Erysodine is a blood-brain barrier-permeable nicotinic acetylcholine receptor (nAChR) ligand with high affinity for α4β2 nAChR, Ki = 5 nM, and it blocks nicotine-induced dopamine release and behavioral effects through competitive inhibition. Erysodine is useful for studies on alcohol dependence. | |||||||||||||||||||||
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References
- [1]. Decker MW, et al. Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors. European journal of pharmacology. 1995 Jun 23;280(1):79-89.
- [2]. KONIUSZY F, et al. Erythrina alkaloids; studies on the constitution of erysodine erysovine and erysopine. J Am Chem Soc. 1949 Mar;71(3):875-8.
- [3]. Mansbach RS, et al. Effects of the competitive nicotinic antagonist erysodine on behavior occasioned or maintained by nicotine: comparison with mecamylamine. Psychopharmacology. 2000 Feb;148(3):234-42.
- [4]. Quiroz G, et al. Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors, decreases ethanol consumption in alcohol-preferring UChB rats. Behavioural brain research. 2018 Sep 03;349:169-176. [Content Brief]
