748119-79-1
Chemical Structure
Ivospemin
Synonym(s): SBP-101
- CAS No.: 748119-79-1
- Formula:C16H38N4O2
- Molecular Weight:318.50
IUPAC Name: (6S,15S)-3,8,13,18-tetraazaicosane-6,15-diol
InChIKey: AFXLPCNTPZQBIC-HOTGVXAUSA-N
SMILES: CCNCC[C@H](O)CNCCCCNC[C@@H](O)CCNCC
Biological Activity: Ivospemin (SBP-101) is an antineoplastic spermine analog. Ivospemin has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin is promising for research of cancers[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ivospemin | 99.89% | Ivospemin (SBP-101) is an antineoplastic spermine analog. Ivospemin has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin is promising for research of cancers. | ||||||||||||||||||||
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- [1]. International Nonproprietary Names for Pharmaceutical Substances (INN).
- [2]. Holbert CE, et al. The Polyamine Analogue Ivospemin Increases Chemotherapeutic Efficacy in Murine Ovarian Cancer. Biomedicines. 2024 May 23;12(6):1157. [Content Brief]
- [3]. Liu TA, et al. The Synergistic Benefit of Combination Strategies Targeting Tumor Cell Polyamine Homeostasis. Int J Mol Sci. 2024 Jul 26;25(15):8173. [Content Brief]
Keywords
