762266-54-6
Chemical Structure
DTLMISR
- CAS No.: 762266-54-6
- Formula:C34H62N10O12S
- Molecular Weight:834.98
InChIKey: HWXMJCBVMKSAFU-CYHBETLTSA-N
SMILES: O=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CO)=O)[C@H](CC)C)=O)CCSC)=O)CC(C)C)=O)[C@@H](C)O
Biological Activity: DTLMISR is a tryptic peptide widely present in the Fc regions of all four human IgG subclasses. DTLMISR contains a methionine residue susceptible to both post-translational modification oxidation and artificial oxidation, and its oxidized form requires specific detection via LC-MRM before SILuMAb aliquoting and storage[1][2][3][4].
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DTLMISR | DTLMISR is a tryptic peptide widely present in the Fc regions of all four human IgG subclasses. DTLMISR contains a methionine residue susceptible to both post-translational modification oxidation and artificial oxidation, and its oxidized form requires specific detection via LC-MRM before SILuMAb aliquoting and storage. | |||||||||||||||||||||
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- [1]. Lesur A, Varesio E, Hopfgartner G. Protein quantification by MALDI-selected reaction monitoring mass spectrometry using sulfonate derivatized peptides. Analytical chemistry. 2010 Jun 15;82(12):5227-37. [Content Brief]
- [2]. Vialaret J, Broutin S, Pugnier C, et al.. What sample preparation should be chosen for targeted MS monoclonal antibody quantification in human serum?. Bioanalysis. 2018 May 01;10(10):723-735. [Content Brief]
- [3]. Hong Q, Lebrilla CB, Miyamoto S, et al.. Absolute quantitation of immunoglobulin G and its glycoforms using multiple reaction monitoring. Analytical chemistry. 2013 Sep 17;85(18):8585-93. [Content Brief]
- [4]. Kleinberg A, Yoon J, Mao Y, et al.. Eliminating liquid chromatography-induced methionine oxidation of monoclonal antibodies using high-concentration TCEP injections: The "anTCEPtic" column cleaning method. Journal of pharmaceutical sciences. 2026 Jun;115(6):104298. [Content Brief]
Keywords
