76410-58-7
Chemical Structure
L-p-Boronophenylalanine
Synonym(s): L-BPA
- CAS No.: 76410-58-7
- Formula:C9H12BNO4
- Molecular Weight:209.01
IUPAC Name: (S)-2-amino-3-(4-boronophenyl)propanoic acid
InChIKey: NFIVJOSXJDORSP-QMMMGPOBSA-N
SMILES: O=C(O)[C@@H](N)CC1=CC=C(B(O)O)C=C1
Biological Activity: L-p-Boronophenylalanine is a boron-containing substrate for L-type amino acid transporters (LAT1 and LAT2). L-p-Boronophenylalanine enters tumor cells by competing with natural amino acids for LAT, selectively accumulating boron in cancer cells. L-p-Boronophenylalanine can be used in boron neutron capture therapy (BNCT). When boron-10 captures thermal neutrons, a nuclear reaction occurs, producing high-energy alpha particles and lithium nuclei, which kill cancer cells at close range with little damage to surrounding tissues. L-p-Boronophenylalanine can be used in cancer research, especially glioblastoma and anaplastic astrocytoma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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L-p-Boronophenylalanine | 99.79% | L-p-Boronophenylalanine is a boron-containing substrate for L-type amino acid transporters (LAT1 and LAT2). L-p-Boronophenylalanine enters tumor cells by competing with natural amino acids for LAT, selectively accumulating boron in cancer cells. L-p-Boronophenylalanine can be used in boron neutron capture therapy (BNCT). When boron-10 captures thermal neutrons, a nuclear reaction occurs, producing high-energy alpha particles and lithium nuclei, which kill cancer cells at close range with little damage to surrounding tissues. L-p-Boronophenylalanine can be used in cancer research, especially glioblastoma and anaplastic astrocytoma. | ||||||||||||||||||||
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References
- [1]. Fukuda T, et al. 4-Iodobenzonitrile as a fluorogenic derivatization reagent for chromatographic analysis of L-p-boronophenylalanine in whole blood samples using Suzuki coupling reaction. Anal Chim Acta. 2024 Jul 18;1313:342700. [Content Brief]
- [2]. Shull Brian K, et al. Evidence for spontaneous, reversible paracyclophane formation. Aprotic solution structure of the boron neutron capture therapy drug, Lp-boronophenylalanine. Journal of the Chemical Society, Perkin Transactions 2 3 (2000): 557-561.
