78524-72-8
Chemical Structure
6"'-Deamino-6"'-hydroxyparomomycin I
- CAS No.: 78524-72-8
- Formula:C23H44N4O15
- Molecular Weight:616.61
InChIKey: VCHIDEKSPVNIGR-VCIWKGPPSA-N
SMILES: O[C@H]([C@@H]([C@H](O1)CO)O[C@H]2O[C@H]([C@H]([C@@H]([C@H]2N)O)O)CO)[C@@H]1O[C@H]([C@H]([C@@H](C[C@@H]3N)N)O)[C@@H]3O[C@H]4O[C@@H]([C@H]([C@@H]([C@H]4N)O)O)CO
Biological Activity: 6"'-Deamino-6"'-hydroxyparomomycin I is an amino glycosyl antibiotic that can be produced by Streptomyces rimosus forma paromomycinus A67 15. It is active against both Gram-positive and Gram-negative bacteria. 6"'-Deamino-6"'-hydroxyparomomycin I can be used as an intermediate in the biosynthesis of paromomycin[1][2].
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6"'-Deamino-6"'-hydroxyparomomycin I | 6"'-Deamino-6"'-hydroxyparomomycin I is an amino glycosyl antibiotic that can be produced by Streptomyces rimosus forma paromomycinus A67 15. It is active against both Gram-positive and Gram-negative bacteria. 6"'-Deamino-6"'-hydroxyparomomycin I can be used as an intermediate in the biosynthesis of paromomycin. | |||||||||||||||||||||
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- [1]. Autissier D, et al. 6"'-Deamino-6"'-hydroxy derivatives, as intermediates in the biosynthesis of neomycin and paromomycin. J Antibiot (Tokyo). 1981 May;34(5):536-43. [Content Brief]
- [2]. Toda S, NAKAGAWA S, NAITO T, et al. AMINOGLYCOSIDE ANTIBIOTICS. XV CHEMICAL CONVERSION OF NEOMYCIN B TO PAROMOMYCIN I, 6'''-DEAMINO-6'''-HYDROXYNEOMYCIN B AND 6'''-DEAMINO-6'''-HYDROXY-PAROMOMYCIN I. The Journal of Antibiotics, 1983, 36(1): 87-91.
Keywords
