825658-63-7
Chemical Structure
RTI-7470-44
- CAS No.: 825658-63-7
- Formula:C19H11ClF3N5OS
- Molecular Weight:449.84
IUPAC Name: (2S)-2-amino-3-(5-hydroxyoctahydro-1H-indol-3-yl-4,6,7-d3)propanoic acid
InChIKey: WHNQNKYKDSLDKM-UHFFFAOYSA-N
SMILES: N#CC1=C(SCC(NC2=NC=CC=N2)=O)N=C(C3=CC=C(Cl)C=C3)C=C1C(F)(F)F
Biological Activity: RTI-7470-44 is an orally active and blood-brain barrier-permeable antagonist of trace amine-associated receptor 1 (hTAAR1) with a Ki of 0.3 nM. RTI-7470-44 inhibits hTAAR1-mediated cAMP production and signal transduction (IC50 = 8.4 nM), and blocks hTAAR1-mediated GIRK current responses. RTI-7470-44 increases the spontaneous firing frequency of dopaminergic neurons and reduces collagen-induced platelet aggregation. RTI-7470-44 can be used in studies related to Parkinson's disease and gastric emptying[1].
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RTI-7470-44 | 99.85% | RTI-7470-44 is an orally active and blood-brain barrier-permeable antagonist of trace amine-associated receptor 1 (hTAAR1) with a Ki of 0.3 nM. RTI-7470-44 inhibits hTAAR1-mediated cAMP production and signal transduction (IC50 = 8.4 nM), and blocks hTAAR1-mediated GIRK current responses. RTI-7470-44 increases the spontaneous firing frequency of dopaminergic neurons and reduces collagen-induced platelet aggregation. RTI-7470-44 can be used in studies related to Parkinson's disease and gastric emptying. | ||||||||||||||||||||
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Keywords
