83677-24-1
Chemical Structure
KME-4
- CAS No.: 83677-24-1
- Formula:C19H26O3
- Molecular Weight:302.41
IUPAC Name: (Z)-3-(3,5-di-tert-butyl-4-hydroxybenzylidene)dihydrofuran-2(3H)-one
InChIKey: DFPYHQJPGCODSB-LCYFTJDESA-N
SMILES: O=C1OCCC1=CC=2C=C(C(O)=C(C2)C(C)(C)C)C(C)(C)C
Biological Activity: KME-4 is an orally active dual inhibitor of 5-lipoxygenase (5-lipoxygenase) and cyclooxygenase (cyclooxygenase). KME-4 inhibits 5-lipoxygenase in the cytosol of guinea pig polymorphonuclear leukocytes (PMNL) and cyclooxygenase in rabbit platelets, with IC50 values of 0.85 μM and 0.44 μM, respectively. KME-4 can be used in studies related to arachidonic acid metabolism, inflammatory responses, and arthritis[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
KME-4 | KME-4 is an orally active dual inhibitor of 5-lipoxygenase (5-lipoxygenase) and cyclooxygenase (cyclooxygenase). KME-4 inhibits 5-lipoxygenase in the cytosol of guinea pig polymorphonuclear leukocytes (PMNL) and cyclooxygenase in rabbit platelets, with IC50 values of 0.85 μM and 0.44 μM, respectively. KME-4 can be used in studies related to arachidonic acid metabolism, inflammatory responses, and arthritis. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Hidaka T, et al. The effect of alpha-(3,5-di-t-butyl-4-hydroxybenzylidene)-gamma-butyrolactone (KME-4), a new anti-inflammatory drug, on leucocyte migration in rat carrageenan pleurisy. The Journal of pharmacy and pharmacology. 1986 Mar;38(3):244-7.
- [2]. Hidaka T, et al. Inhibition of polymorphonuclear leukocyte 5-lipoxygenase and platelet cyclooxygenase by alpha-(3,5-di-tert-butyl-4-hydroxybenzylidene)-gamma-butyrolacto ne (KME-4), a new anti-inflammatory drug. Japanese journal of pharmacology. 1985 Jul;38(3):267-72.
- [3]. Hidaka T, et al. Effect of alpha-(3,5-di-tert-butyl-4-hydroxybenzylidene)-gamma-butyrolactone (KME-4), a new anti-inflammatory drug, on the established adjuvant arthritis in rats. Japanese journal of pharmacology. 1986 Oct;42(2):181-7.
- [4]. Hidaka T, et al. Analgesic and anti-inflammatory activities in rats of alpha-(3,5-di-t-butyl-4-hydroxybenzylidene)-gamma-butyrolactone (KME-4), and its intestinal damage. The Journal of pharmacy and pharmacology. 1986 Oct;38(10):748-53.
- [5]. Hidaka T, et al. Pharmacological properties of a new anti-inflammatory compound, alpha-(3,5-di-tert-butyl-4-hydroxybenzylidene)-gamma-butyrolacto ne (KME-4), and its inhibitory effects on prostaglandin synthetase and 5-lipoxygenase. Japanese journal of pharmacology. 1984 Sep;36(1):77-85.
