851658-28-1
Chemical Structure
RSV L-protein-IN-5
- CAS No.: 851658-28-1
- Formula:C31H36N6O4
- Molecular Weight:556.66
InChIKey: ZQJFKHMZMLDZIV-UHFFFAOYSA-N
SMILES: O=C1C2=C(C(C)(C)C(N1CCCNCCC3=CC=C(C(OC)=C3)OC)=O)C=C(N)C4=C2NC(C5=CC=CC(C)=N5)=N4
Biological Activity: RSV L-protein-IN-5 (compound E) is a potent inhibitor of Respiratory syncytial virus (RSV) (EC50=0.1 μM). RSV L-protein-IN-5 inhibits Polymerase (IC50=0.66 μM)，and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-5 shows moderate cytotoxicity (CC50=10.7 μM，HEp-2)，also exhibits activity and lowers virus titers in mouse models of RSV infection[1].
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RSV L-protein-IN-5 | RSV L-protein-IN-5 (compound E) is a potent inhibitor of Respiratory syncytial virus (RSV) (EC50=0.1 μM). RSV L-protein-IN-5 inhibits Polymerase (IC50=0.66 μM)，and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-5 shows moderate cytotoxicity (CC50=10.7 μM，HEp-2)，also exhibits activity and lowers virus titers in mouse models of RSV infection. | |||||||||||||||||||||
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Keywords
