859171-97-4
Chemical Structure
6-Iodonordihydrocapsaicin
- CAS No.: 859171-97-4
- Formula:C17H26INO3
- Molecular Weight:419.30
IUPAC Name: N-(4-hydroxy-2-iodo-5-methoxybenzyl)nonanamide
InChIKey: AAORACFZMYMFCG-UHFFFAOYSA-N
SMILES: CCCCCCCCC(NCC1=CC(OC)=C(O)C=C1I)=O
Biological Activity: 6-Iodonordihydrocapsaicin is a TRPV1 antagonist. 6-Iodonordihydrocapsaicin functionally blocks TRPV1-mediated responses, including capsaicin-induced ion currents in dorsal root ganglion neurons and distension-induced firing of jejunal spinal afferent fibers in mice. 6-Iodonordihydrocapsaicin can be used in the research of visceral pain and anxiety disorders[1][2].
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6-Iodonordihydrocapsaicin | 6-Iodonordihydrocapsaicin is a TRPV1 antagonist. 6-Iodonordihydrocapsaicin functionally blocks TRPV1-mediated responses, including capsaicin-induced ion currents in dorsal root ganglion neurons and distension-induced firing of jejunal spinal afferent fibers in mice. 6-Iodonordihydrocapsaicin can be used in the research of visceral pain and anxiety disorders. | |||||||||||||||||||||
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- [1]. Perez-Burgos A, et al. The TRPV1 channel in rodents is a major target for antinociceptive effect of the probiotic Lactobacillus reuteri DSM 17938. J Physiol. 2015;593(17):3943-3957. [Content Brief]
- [2]. Fogaça MV, et al. Anxiogenic-like effects induced by hemopressin in rats. Pharmacol Biochem Behav. 2015;129:7-13. [Content Brief]
Keywords
