6-Iodonordihydrocapsaicin
6-Iodonordihydrocapsaicin is a TRPV1 antagonist. 6-Iodonordihydrocapsaicin functionally blocks TRPV1-mediated responses, including capsaicin-induced ion currents in dorsal root ganglion neurons and distension-induced firing of jejunal spinal afferent fibers in mice. 6-Iodonordihydrocapsaicin can be used in the research of visceral pain and anxiety disorders.
For research use only. We do not sell to patients.
- CAS No.: 859171-97-4
- Formula: C17H26INO3
- Molecular Weight:419.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TRPV1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
10 nM
Compound: 4b
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Inhibition of 100 nM capsaicin effect on intracellular [Ca2+] concentration in HEK293 cells expressing human TRPV1
Inhibition of 100 nM capsaicin effect on intracellular [Ca2+] concentration in HEK293 cells expressing human TRPV1
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[PMID: 16000002] |
6-Iodonordihydrocapsaicin (10 μM) inhibits capsaicin-evoked ionic currents in murine DRG primary cultures[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (male, 230-250 g)[2]
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Dosage:1 nmol
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Administration:intracerebroventricular (i.c.v.); single administration
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Result:Abolished the anxiogenic-like effect of intracerebroventricular hemopressin, as evidenced by reversal of hemopressin-induced decreases in percentage of open arm entries and percentage of time spent in open arms (restored to levels comparable to vehicle-treated controls).
Caused no significant changes in enclosed arm entry counts.
Chemical Information
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CAS No. 859171-97-4
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Molecular Weight 419.30
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Formula C17H26INO3
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SMILES
CCCCCCCCC(NCC1=CC(OC)=C(O)C=C1I)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Perez-Burgos A, et al. The TRPV1 channel in rodents is a major target for antinociceptive effect of the probiotic Lactobacillus reuteri DSM 17938. J Physiol. 2015;593(17):3943-3957. [Content Brief]
[2]. Fogaça MV, et al. Anxiogenic-like effects induced by hemopressin in rats. Pharmacol Biochem Behav. 2015;129:7-13. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
6-Iodonordihydrocapsaicin Related Classifications
HY-108459 Related Classifications
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