85921-53-5
Chemical Structure
Moveltipril calcium
Synonym(s): MC-838 calcium
- CAS No.: 85921-53-5
- Formula:C19H29CaN2O5S.1/2Ca
- Molecular Weight:417.51
SMILES: O=C(C1CCCCC1)N[C@H](C)C(SC[C@@H](C)C(N2[C@@H](CCC2)C([O-])=O)=O)=O.[0.5].[Ca+2]
Biological Activity: Moveltipril calcium (MC-838 calcium) is an orally active angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Moveltipril calcium binds via a stable thioester bond and exhibits relative resistance to enzymatic hydrolysis in rat liver homogenate. Moveltipril calcium effectively inhibits ACE extracted from rabbit lung in a concentration-dependent manner. Moveltipril calcium is able to highly specifically inhibit the contractile response to angiotensin-I (AI) in free rat aortic rings and guinea pig ileum preparations, while enhancing the contractile response to calcitonin[1].
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Moveltipril calcium | Moveltipril calcium (MC-838 calcium) is an orally active angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Moveltipril calcium binds via a stable thioester bond and exhibits relative resistance to enzymatic hydrolysis in rat liver homogenate. Moveltipril calcium effectively inhibits ACE extracted from rabbit lung in a concentration-dependent manner. Moveltipril calcium is able to highly specifically inhibit the contractile response to angiotensin-I (AI) in free rat aortic rings and guinea pig ileum preparations, while enhancing the contractile response to calcitonin. | |||||||||||||||||||||
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