870603-16-0
870603-16-0
Chemical Structure
XL-281
Synonym(s): BMS-908662
- CAS No.: 870603-16-0
- Formula:C24H19ClN4O4
- Molecular Weight:462.89
IUPAC Name: methyl (6-(2-(5-chloro-2-methylphenyl)-1-hydroxy-3-oxoisoindolin-1-yl)-1H-benzo[d]imidazol-2-yl)carbamate
InChIKey: MMNNTJYFHUDSKL-UHFFFAOYSA-N
SMILES: O=C(OC)NC1=NC2=CC=C(C3(O)N(C4=CC(Cl)=CC=C4C)C(C5=C3C=CC=C5)=O)C=C2N1
Biological Activity: XL-281 (BMS-908662) is an orally active inhibitor for RAF kinase, with IC50s of 2.6, 4.5 and 6 nM, for CRAF, B-RAF, and B-RAFV600E, respectively. XL-281 exhibits antitumor activity[1].
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XL-281 | XL-281 (BMS-908662) is an orally active inhibitor for RAF kinase, with IC50s of 2.6, 4.5 and 6 nM, for CRAF, B-RAF, and B-RAFV600E, respectively. XL-281 exhibits antitumor activity. | |||||||||||||||||||||
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References
Keywords
