872726-44-8
872726-44-8
Chemical Structure
GW 610
Synonym(s): NSC 721648
- CAS No.: 872726-44-8
- Formula:C15H12FNO2S
- Molecular Weight:289.32
IUPAC Name: 2-(3,4-dimethoxyphenyl)-5-fluorobenzo[d]thiazole
InChIKey: ZRLSVQBGBBYEAZ-UHFFFAOYSA-N
SMILES: FC1=CC=C(SC(C2=CC=C(OC)C(OC)=C2)=N3)C3=C1
Biological Activity: GW 610 (NSC 721648), an antitumor agent, is a potent AhR ligand with a Ki of 6.8 nM. GW 610 induces CYP1A1 expression in MCF-7 cells. GW 610 shows potent and selective anticancer activity against lung, colon, and breast cancer cell lines[1].
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GW 610 | 99.78% | GW 610 (NSC 721648), an antitumor agent, is a potent AhR ligand with a Ki of 6.8 nM. GW 610 induces CYP1A1 expression in MCF-7 cells. GW 610 shows potent and selective anticancer activity against lung, colon, and breast cancer cell lines. | ||||||||||||||||||||
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References
- [1]. Mortimer CG, et, al. Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines. J Med Chem. 2006 Jan 12;49(1):179-85. [Content Brief]
Keywords
